INTEGRA™ Flowable Wound Matrix

INTEGRA™ Flowable Wound Matrix is an advanced wound care matrix comprised of a
granulated cross-linked bovine tendon collagen and glycosaminoglycan.

The granulated collagen-glycosaminoglycan is hydrated with saline and applied in difficult to access wound sites and tunneled wounds. It provides a scaffold for cellular invasion and capillary growth.

Wound Healing Model

The images are from a guinea pig wound healing model. The healing response of deep wounds created in the dorsal muscles were evaluated at 2, 4, 8 and 19 weeks following treatment with INTEGRA™ Flowable Wound Matrix. Histologic sections revealed good contact of the material with wound margins throughout the healing process. Wounds containing INTEGRA™ Flowable Wound Matrix were associated with extensive and rapid ingrowth of cells and vascularization followed.

Week 2

Cells (C) rapidly begin to migrate from wound margins into INTEGRA™ Flowable Wound Matrix (IFWM).

Week 4

Cells continue to proliferate and migrate throughout the wound area and blood
vessels (BV) begin to grow into the (IFWM).

Week 8

Cells actively deposit new tissue matrix
within (IFWM). Flowable Wound Matrix maintains good contact with skeletal
muscles (SM).

Week 19

New tissue (NT) is present and continues
to mature.