| INTEGRA™
Meshed Bilayer Wound Matrix is placed on a
surgically debrided or excised wound. It provides
the needed framework for the blood vessels and dermal
skin cells to remodel the damaged site.
As skin cells migrate into the
matrix, the collagen is slowly absorbed and replaced
with collagen produced from the person's own cells.
In approximately 14 to 21 days, the scaffold is
eventually remodeled as the patient's cells rebuild
the damaged site. Complete wound closure occurs
as epidermal cells migrate from the wound edges.
For larger wounds, a thin skin
graft of the person's epidermis may be applied to
the wound area to facilitate complete wound closure.
Wound closure is typically
complete within 30 days. A person is left with a
healed wound created from their own tissue.
Clinical Sequence
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DAY 0:
PRE-TREATMENT
Patients must have accurate
diagnosis and treatment of underlying disease
and risks. There must be thorough pre-operative
control of inflammation, ulceration, debris
and bioburden, and edema (as best as the disease
and available treatments permit).
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DAY 1:
DEBRIDEMENT
Prepare wound bed using
standard methods to ensure wound is free of
debris and necrotic tissue. Regardless of
how well the wound has been prepared and how
healthy it looks, INTEGRA™ Meshed Bilayer Wound Matrix must not be placed
on an existing wound surface. The entire existing
wound must be completely excised or surgically
debrided to ensure the wound bed and edges
contain viable tissue.
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DAY 1:
APPLICATION
INTEGRA™
Meshed Bilayer Wound Matrix is applied
to the excised wound bed. Fluids invade the
matrix within minutes of application, adhering
it to the wound. The INTEGRA™
Meshed Bilayer Wound Matrix must conform
to and contact the wound surface. It can be
affixed with sutures, staples, or any suitable
alternative.
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DAY 7-14:
CELLULAR INVASION and CAPILLARY GROWTH
Cells begin migrating into
the matrix and establish a new vascular network.
The scaffold is eventually remodeled as the
patient's cells rebuild the damaged site.
The collagen template biodegrades
and is absorbed into the body.
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DAY 21+:
SILICONE REMOVAL
The silicone layer is
removed. The collagen template biodegrades
and is absorbed into the body.
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DAY 21-56+:
WOUND CLOSURE
Epidermal cells migrate
from the wound edges to complete wound closure.
For larger wounds, a thin epidermal autograft
may be considered to facilitate wound closure.
A thin 0.004 – 0.006 in. (0.1016 - 0.1524
mm) epidermal autograft may be applied over
the new remodeled skin.
Epidermal coverage over the wound yields a permanant
and lasting wound closure. |
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