When INTEGRA® Template is placed
on a wound where burned or scarred skin has been removed,
INTEGRA provides the needed framework for the blood
vessels and dermal skin cells to re-grow into a new
skin layer. The silicone outer layer temporarily closes
the wound to ward off infection and control fluid
and heat loss.
As skin cells migrate into the
matrix the collagen is slowly absorbed into the
body and replaced with protein that is naturally
produced by the skin. In approximately 14 to 21
days, new dermal skin is produced and the silicone
layer can be removed. A thin skin graft of the person's
epidermis is applied to the wound area to complete
the procedure.
In total, the two surgical
procedures are typically completed within 30 days.
A person is left with flexible growing skin and
minimal damage at the skin graft donor sites.
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This video illustrates the process
of dermal regeneration from reconstructive surgery. |
Clinical Sequence
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DAY 0:
PRE-TREATMENT
The burn injury or scar
contracture is assessed and evaluated
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DAY 1:
EXCISION
The wound is cleaned and
the damaged tissue or contracture scar is
completely excised (removed) down to viable
tissue in preparation for the application
of the INTEGRA® Template
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DAY 1:
APPLICATION
INTEGRA® Template
is applied to the excised wound bed. Fluids
invade the matrix within minutes of application,
adhering it to the wound.
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DAY 7-14:
NEW DERMIS FORMATION
Dermal cells begin migrating
into the matrix and establish a new vascular
network. As healing progresses, the
collagen (protein) in the INTEGRA® Template
is replaced by collagen organically produced
by new dermal
skin cells.
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DAY 21+:
SILICONE REMOVAL
Upon formation of a new
dermal layer, the INTEGRA silicone layer is
removed. The INTEGRA collagen template biodegrades
and is absorbed into the body, leaving new
dermal skin.
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DAY 21+:
EPIDERMAL AUTOGRAFT
A thin 0.004 –
0.006 in. (0.1016 - 0.1524 mm) epidermal autograft
is applied over the new dermal skin
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DAY 25-56:
REGENERATED SKIN
Successful engraftment completes
the procedure yielding a permanent and lasting
wound closure
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