Wound Bed Preparation
    Application Guidelines
    Estimating the Number and Size of Sheets
    Product Preparation
    Placement, Shaping and Cutting
  Post-Op Care

Stapling and Suturing
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  • Stapling, suturing or other suitable alternative may be used
  • Any air bubbles should be carefully removed to maintain contact with the wound
  • Fix sheets independently and/or affix adjacent sheets together to minimize gaps so granulation tissue formation is reduced
  • Interrupted stapling (i.e., leaving a 1-2 centimeter space between staples) can be used to
    seal edges
  • Plan staple lines carefully, follow Langer's Lines

Application Techniques

  • Place INTEGRA™ Meshed Bilayer Wound Matrix following normal "Z Plasty" techniques to
    relieve tension over joints and minimize dislodgement
  • After initial stapling check for pulling or creases in the INTEGRA™ Meshed Bilayer Wound
    sheets - particularly when over joints

        - Cut to release tension

        - "Seal" the new cut edges with interrupted staples placed close together

When Used With Negative Pressure Therapy

  • Apply Negative Pressure Wound Therapy Device according to manufacturer’s instructions
    for use, paying specific attention to contraindications, warnings, and precautions

    Where applicable, follow instructions for “Meshed Grafts
    and Bioengineered Tissues”

  • For pressure settings, refer to instructions for use for the specific device utilized and type
    of wound, if applicable


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